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[1]金梦莹 陈金凤 曹钰镁 沈芋蓉 李新爱 侯胜宏 郭大乐 罗禹**.尖海龙共附生真菌Talaromyces amestolkiae的化学成分[J].应用与环境生物学报,2020,26(04):1-6.[doi:10.19675/j.cnki.1006-687x.2019.10007]
 JIN Mengying,CHEN Jinfeng,CAO Yumei,et al.Study on the chemical constituents of Talaromyces amestolkiae, a symbiotic Fungus of Syngnathus acus Linnaeus[J].Chinese Journal of Applied & Environmental Biology,2020,26(04):1-6.[doi:10.19675/j.cnki.1006-687x.2019.10007]
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尖海龙共附生真菌Talaromyces amestolkiae的化学成分()
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《应用与环境生物学报》[ISSN:1006-687X/CN:51-1482/Q]

卷:
26卷
期数:
2020年04期
页码:
1-6
栏目:
研究论文
出版日期:
2020-08-25

文章信息/Info

Title:
Study on the chemical constituents of Talaromyces amestolkiae, a symbiotic Fungus of Syngnathus acus Linnaeus
作者:
金梦莹1 陈金凤1 曹钰镁1 沈芋蓉1 李新爱1 侯胜宏3 郭大乐1 罗禹2**
1成都中医药大学药学院中药材标准化教育部重点实验室,四川省中药资源系统研究与开发利用重点实验-省部共建国家重点实验室培育基地 成都 611137
2西南医科大学药学院 泸州 646000 3
四川禾亿制药有限公司 成都 611630
Author(s):
JIN Mengying1 CHEN Jinfeng1 CAO Yumei1 SHEN Yurong1 LI Xinai1 HOU Shenghong 3 GUO Dale1 LUO Yu2** & DENG Yun1**
1Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Sichuan provincial Key Laboratory of Systematic Research, Development and Utilization of Chinese Medical Resources: Ministry of State Key Laboratory Breeding Base, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China 2School of Pharmacy, Southwest Medical University, Luzhou 646000, China 3Sichuan Heyi Pharmaceutical Co., Ltd, Chengdu 611630, China
关键词:
尖海龙共附生真菌Talaromyces amestolkiae化学成分
Keywords:
Syngnathus acus Linnaeus symbiotic fungus Talaromyces amestolkiae chemical constituent
DOI:
10.19675/j.cnki.1006-687x.2019.10007
摘要:
对尖海龙共附生真菌Talaromyces amestolkiae的化学成分进行研究。采用固体培养基对该菌株进行培养,利用硅胶柱、Sephdex-LH-20凝胶柱、MCI柱、制备色谱等方法对化学成分进行分离纯化,并运用质谱、核磁共振等方法进行结构鉴定。本文共分离得到10个化合物,分别为methyl 2-formyl-4-methylfuro[3, 2-b]pyrrole-5-carboxylate(1)、4-甲基苔黑酚(2)、麦角甾-5, 7, 22-三烯-3-醇(3)、3-甲氧基苯酚(4)、thailandolide B (5)、aspergillumarin B (6)、(R)-3-(3-hydroxypropyl)-8-hydroxy-3, 4-dihydroisocoumarin(7)3-hydroxymethyl-6, 8-dimethoxycoumarin(8)、penicifuran D (9)、penicifuran C (10)。其中化合物1为首次分离得到的天然产物,化合物2-10均首次从T. amestolkiae中分离。
Abstract:
To study the chemical constituents of Talaromyces amestolkiae, a symbiotic fungus obtained from Syngnathus acus Linnaeus . T. amestolkiae was cultured with solid state fermentation and its secondary metabolites were separated by silica gel, Sephadex LH-20, MCI column, and preparative chromatography.The compounds were identified by spectral methods. Ten compounds were isolated and identified as methyl 2-formyl-4-methylfuro[3, 2-b]pyrrole-5-carboxylate (1), 4-methylorcnol(2), erg osta-5, 7, 22-trien-3-ol ( 3), 3-methoxyphenol (4), thailandolide B ( 5), aspergillumarin B ( 6), (R)-3-(3-hydroxypropyl)-8-hydroxy-3, 4-dihydroisocoumarin (7), 3-hydroxymethyl-6, 8-dimethoxycoumarin (8), penicifuran D (9), penicifuran C (10)。 Compound 1 is the new natural product to be isolated. Compounds 2- 10 were isolated from this genus for the first time.

备注/Memo

备注/Memo:
收稿日期 Received: 2019-10-09 接受日期 Accepted: 2019-11-21
*国家自然科学基金面上项目(81373961);四川省科技厅省青年科技创新研究团队专项计划(2016TD0006);中国博士后科学基金(2017M622985);四川省教育厅科研项目(18ZA0191);成都中医药大学青年教师创新基金(ZRQN1766)资助
**通讯作者 Corresponding authors(dengyun@cdutcm.edu.cn; uoyu@163.com)
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更新日期/Last Update: 2019-12-05