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[1]金梦莹,陈金凤,曹钰镁,等.尖海龙共附生真菌Talaromyces amestolkiae的化学成分[J].应用与环境生物学报,2020,26(05):1230-1234.[doi: 10.19675/j.cnki.1006-687x.2019.10007]
 JIN Mengying,CHEN Jinfeng,CAO Yumei,et al.Chemical constituents of Talaromyces amestolkiae, a symbiotic fungus of Syngnathus acus[J].Chinese Journal of Applied & Environmental Biology,2020,26(05):1230-1234.[doi: 10.19675/j.cnki.1006-687x.2019.10007]
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尖海龙共附生真菌Talaromyces amestolkiae的化学成分()
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《应用与环境生物学报》[ISSN:1006-687X/CN:51-1482/Q]

卷:
26卷
期数:
2020年05期
页码:
1230-1234
栏目:
研究论文
出版日期:
2020-10-25

文章信息/Info

Title:
Chemical constituents of Talaromyces amestolkiae, a symbiotic fungus of Syngnathus acus
作者:
金梦莹陈金凤曹钰镁沈芋蓉李新爱侯胜宏郭大乐罗禹邓赟
1成都中医药大学药学院中药材标准化教育部重点实验室,四川省中药资源系统研究与开发利用重点实验-省部共建国家重点实验室培育基地 成都 611137 2西南医科大学药学院 泸州 646000 3四川禾亿制药有限公司 成都 611630
Author(s):
JIN Mengying1 CHEN Jinfeng1 CAO Yumei1 SHEN Yurong1 LI Xinai1 HOU Shenghong3 GUO Dale1 LUO Yu2? & DENG Yun1?
1 Key Laboratory of Standardization of Chinese Herbal Medicine of Ministry of Education; Sichuan Provincial Key Laboratory of Systematic Research, Development and Utilization of Chinese Medical Resources: Ministry of State Key Laboratory Breeding Base; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China 2 School of Pharmacy, Southwest Medical University, Luzhou 646000, China 3 Sichuan Heyi Pharmaceutical Co., Ltd, Chengdu 611630, China
关键词:
尖海龙共附生真菌Talaromyces amestolkiae化学成分
Keywords:
Syngnathus acus Linnaeus symbiotic fungus Talaromyces amestolkiae chemical constituent
DOI:
10.19675/j.cnki.1006-687x.2019.10007
摘要:
对尖海龙共附生真菌Talaromyces amestolkiae的化学成分进行研究. 采用固体培养基对该菌株进行培养,利用硅胶柱、Sephdex-LH-20凝胶柱、MCI柱、制备色谱等方法对化学成分进行分离纯化,并运用质谱、核磁共振等方法进行结构鉴定. 共分离得到10个化合物,分别为methyl 2-formyl-4-methylfuro[3,2-b]pyrrole-5-carboxylate(1)、4-甲基苔黑酚(2)、麦角甾-5,7,22-三烯-3-醇(3)、3-甲氧基苯酚(4)、thailandolide B(5)、aspergillumarin B(6)、(R)-3-(3-hydroxypropyl)-8-hydroxy-3,4-dihydroisocoumarin(7)3-hydroxymethyl-6,8-dimethoxycoumarin(8)、penicifuran D(9)、penicifuran C(10). 其中化合物1为首次分离得到的天然产物,化合物2-10均首次从T. amestolkiae中分离. (参33)
Abstract:
This study focused on the chemical constituents of Talaromyces amestolkiae, a symbiotic fungus obtained from Syngnathus acus Linnaeus. Talaromyces amestolkiae was cultured with solid-state fermentation, and its secondary metabolites were separated by silica gel, Sephadex LH-20, MCI column, as well as preparative chromatography. The subsequent compounds were identified by spectral methods. Ten compounds were isolated and identified as methyl 2-formyl-4-methylfuro[3,2-b]pyrrole-5-carboxylate (1), 4-methylorcnol (2), erg osta-5,7,22-trien-3-ol (3),3-methoxyphenol (4), thailandolide B (5), aspergillumarin B (6), (R)-3-(3-hydroxypropyl)-8-hydroxy-3,4-dihydroisocoumarin (7), 3-hydroxymethyl-6,8-dimethoxycoumarin (8), penicifuran D (9), penicifuran C (10). Compound 1 was obtained from natural source for the first time. Compounds 2-10 were isolated from this genus for the first time.

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更新日期/Last Update: 2020-10-25