1 赵国辉, 寿伟椿. 军用毒剂化学[M]. 北京: 中国人民解放军防化学院, 1985 [Zhao GH, Shou WC. Military Chemical Agent [M]. Beijing: Anti Chemical Command and Engineering Institute of the Chinese People Liberation Army, 1985] 2 Oudejans L, Wyrzykowska-Ceradini B, Williams C, Tabor D, Martinez J. Impact of environmental conditions on the enzymatic decontamination of a material surface contaminated with chemical warfare agent simulants [J]. Ind Eng Chem Res, 2013, 52: 10072-10079 3 Prokop Z, Oplustil F, DeFrank J, Damborsky J. Enzymes fight chemical weapons [J]. Biotechnol J, 2006, 1: 1370-1380 4 Prokop Z, Damborsky J, Oplustil F, Jesenska A, Nagata Y. Method of detoxification of yperite by using haloalkane dehalogenases [P]. US 7,888,103 B2, 2011 5 习海玲, 刘昌财, 问县芳, 陈立坤. 卤代烷烃脱卤酶及其对芥子气的降解研究进展[J]. 应用与环境生物学报 2015, 21 (5): 842-847 [Xi HL, Liu CC, Wen XF, Chen LK. Advances in research on haloalkane dehalogenases and its sulfur mustard degradation function [J]. Chin J Appl Environ Biol, 2015, 21 (5): 842-847] 6 Guo N, Liu JQ, Dong ZY, Zhong JY, Kong LC. Study on catalytic hydrolysis of sulfur mustard by the haloalkane dehalogenases [J]. Environ Chem, 2015, 7: 57-65 7 Belkin S. Biodegradation of haloalkanes [J]. Biodegradation, 1992, 3: 299-313 8 Klvana M, Pavlova M, Koudelakova T, Chaloupkova R, Dvorak P, Prokop Z, Stsiapanava A, Kuty M, Kuta-Smatanova I, Dohnalek J, Kulhanek P, Wade RC, Damborsky J. Pathways and mechanisms for product release in the engineered haloalkane dehalogenases explored using classical and random acceleration molecular dynamics simulations [J]. J Mol Biol, 2009, 392: 1339-1356 9 Pavlova M, Klvana M, Prokop Z, Chaloupkova R, Banas P, Otyepka M, Wade RC, Tsuda M, Nagata Y, Damborsky J. Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate [J]. Nat Chem Biol, 2009, 5: 727-33 10 Koudelakova T, Chaloupkova R, Brezovsky J, Prokop Z, Sebestova E, Hesseler M, Khabiri M, Plevaka M, Kulik D, Kuta Smatanova I, Rezacova P, Ettrich R, Bornscheuer UT, Damborsky J. Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel [J]. Angew Chem, 2013, 52: 1959-63