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[1]刘子超,梁醒财.除虫菊酯和迷迭香对大鼠大脑突触体ATP酶的活性影响[J].应用与环境生物学报,2008,14(03):399-402.
 LIU Zichao,et al..Effect of Pyrethrins and Rosemary on the ATPase Activities of Rat Cerebral Synaptosome[J].Chinese Journal of Applied & Environmental Biology,2008,14(03):399-402.
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除虫菊酯和迷迭香对大鼠大脑突触体ATP酶的活性影响()
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《应用与环境生物学报》[ISSN:1006-687X/CN:51-1482/Q]

卷:
14卷
期数:
2008年03期
页码:
399-402
栏目:
综述
出版日期:
2008-03-25

文章信息/Info

Title:
Effect of Pyrethrins and Rosemary on the ATPase Activities of Rat Cerebral Synaptosome
作者:
刘子超梁醒财
Author(s):
LIU Zichao et al.
Keywords:
Keywords pyrethrin rosemary total ATPase Mg2+ATPase rat cerebral synaptosome
Abstract:
Abstract Pyrethrins are the widely used insecticides in agriculture and households, and they act on integral membrane proteins, causing neurotoxic effects on animals. Rosemary, as an antioxidant, is developed to improve the stability of pyrethrins and applied for many commercially pyrethrinrelated products. This paper aimed to study the effects of pyrethrins and rosemary, as well as their combination on the cerebral synaptosome ATPase of rat. The Percoll gradient method was used to isolate synaptosomes. Total ATPase and Mg2+ATPase activities were analyzed by determining the amount of inorganic phosphate. The results indicated that the activities of total ATPase and Mg2+ATPase in 10 μmol/L pyrethrins were reduced to 80.3% and 46.9%, respectively, compared with CK. However, rosemary at concentration of 0.3 to 30 μmol/L showed little effect on ATPase, while at the concentration of 3 000 μmol/L, the total ATPase and the Mg2+ATPase activities were decreased to 66.8% and 54.5%, respectively. The mixture of 10 μmol/L pyrethrin and 30 μmol/L rosemary decreased the activities of the total ATPase and Mg2+ATPase to 72.9% and 33.4%, respectively. It is concluded that pyrethrins can inhibit ATPase activity of rat cerebral synaptosome dramatically; rosemary inhibits ATPase only at high concentration; and rosemary slightly enhances inhibition of pyrethrins on ATPase activity. Fig 3, Ref 19
更新日期/Last Update: 2008-07-01