[1]姚建 苟敏 汤岳琴**.[综 述]“绿色塑料” 聚羟基脂肪酸酯生物合成研究进展[J].应用与环境生物学报,2021,27(04):1-18.[doi:10.19675/j.cnki.1006-687x.2020.08007]
YAO Jian,GOU Min,TANG Yueqin**.Research Progress on biosynthesis of "Green Plastics" -Polyhydroxyalkanoates[J].Chinese Journal of Applied & Environmental Biology,2021,27(04):1-18.[doi:10.19675/j.cnki.1006-687x.2020.08007]
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[综 述]“绿色塑料” 聚羟基脂肪酸酯生物合成研究进展()
YAO Jian,GOU Min,TANG Yueqin**.Research Progress on biosynthesis of "Green Plastics" -Polyhydroxyalkanoates[J].Chinese Journal of Applied & Environmental Biology,2021,27(04):1-18.[doi:10.19675/j.cnki.1006-687x.2020.08007]
《应用与环境生物学报》[ISSN:1006-687X/CN:51-1482/Q]
- 卷:
- 27卷
- 期数:
- 2021年04期
- 页码:
- 1-18
- 栏目:
- 综 述
- 出版日期:
- 2021-08-25
文章信息/Info
- Title:
- Research Progress on biosynthesis of "Green Plastics" -Polyhydroxyalkanoates
- Keywords:
- polyhydroxyalkanoates; PHAs synthesis; genetic engineering; metabolic engineering; mixed microbial cultures
- 摘要:
- 由于化石资源日益枯竭和塑料污染加剧，迫切需求环境友好可降解的“绿色塑料”。由细菌合成的具有良好生物降解性和生物相容性的聚羟基脂肪酸酯（Polyhydroxyalkanoates，PHAs）被认为是最有前景的“绿色塑料”之一。本文概述PHAs的结构、材料特性和应用、生物合成代谢路径以及发酵方式，指出高昂的生产成本是限制PHAs大规模生产和应用的关键问题；总结以降低PHAs生产成本为目标的PHAs生物合成研究进展，包括PHAs合成菌株的基因工程和代谢工程优化、在开放条件下使用富集菌群发酵、以及采用极端微生物合成特定PHAs。以低品质废弃生物质为原料，在开放条件下利用富集菌群合成PHAs的研究尤其受到关注，是废弃生物质高值资源化利用的一条重要途径。未来的研究中需进一步对PHAs生产菌株的合成能力以及生产工艺的效率进行提升；对基于富集菌群的PHAs生产，需对菌群结构和功能调控进行深入研究，构建稳定高效的PHAs合成菌群和工艺流程，以实现PHAs的低成本合成和广泛应用。
- Abstract:
- Due to the depletion of fossil resources and the serious plastic pollution , there is a urgent need for environmentally friendly “green plastics”. Polyhydroxyalkanoates (PHAs) synthesized by bacteria have biodegradability and biocompatibility and are considered to be one of the most promising “green plastics”. This review summarized the structure, material properties and applications of PHAs, the biosynthetic metabolic pathways and the fermentation modes, and points out that the high production cost is the key problem limiting the large-scale PHAs production and application. The research progress of PHAs biosynthesis aimed at reducing the production cost of PHAs was summarized, including genetic engineering and metabolic engineering optimization of PHAs synthesizing strains, fermentation with enriched flora under open conditions, and synthesis of specific PHAs by extreme microorganisms. Especially, the study on the PHAs synthesis with enriched floras under open conditions using low-quality waste biomass as raw material has attracted more attention. PHAs production is an important way for high-value resource utilization of waste biomass. In the future research, in order to achieve low-cost synthesis and wide application of PHAs, it is necessary to further improve the PHAs synthesis ability of the production strains as well as the efficiency of the production process. For enriched flora-based PHAs production, to deeply study the structure and function of microbial floras is crucial for constructing stable and efficient PHAs synthesis floras and efficient process.
相似文献/References:
[1]杨姗姗,张红蕊,伏圣秘,等.一株产聚羟基脂肪酸酯根瘤菌Rhizobium sp. H2-5的筛选与鉴定[J].应用与环境生物学报,2013,19(02):375.[doi:10.3724/SP.J.1145.2013.00375]
YANG Shanshan,ZHANG Hongrui,FU Shengmi,et al.Screening and Identification of a Polyhydroxyalkanoate Producing Strain Rhizobium sp. H2-5[J].Chinese Journal of Applied & Environmental Biology,2013,19(04):375.[doi:10.3724/SP.J.1145.2013.00375]
备注/Memo
- 备注/Memo:
-
收稿日期 Received: 2020-08-04 接受日期 Accepted: 2020-09-30
国家自然基金科学基金项目（51678378）资助
**通讯作者 Corresponding author (E-mail: tangyq@scu.edu.cn)
引用本文请注明出处本刊；发表刊期和页码将以正式出版时的安排为准，但DOI确定不变。
更新日期/Last Update:
2020-10-05