|本期目录/Table of Contents|

 WANG Yong,REN Yafeng,LI Dongxue,et al.The interaction of heat shock proteins and some components of plant viruses[J].Chinese Journal of Applied & Environmental Biology,2018,24(02):415-424.[doi:10.19675/j.cnki.1006-687x.2017.03013]





The interaction of heat shock proteins and some components of plant viruses
1贵州大学绿色农药与农业生物工程国家重点实验室培育基地 贵阳 550025
WANG Yong REN Yafeng LI Dongxue CHEN Zhuo
1 State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guiyang 550025, China 2 College of Agriculture, Guizhou University, Guiyang 550025, China
heat shock protein (Hsp) plant virus plant host interaction mechanism
Q51 : S432
1贵州大学绿色农药与农业生物工程国家重点实验室培育基地 贵阳 550025 2贵州大学农学院 贵阳 550025 摘 要 大量研究表明热休克蛋白(Heat shock protein,Hsp)作为分子伴侣蛋白,通过对招募蛋白的折叠、转运、定位、装配或降解等行为参与植物病毒的生命活动;明确病毒与植物寄主互作机制对于培育抗病毒品种和开发新型抗病毒农药具有重要意义. 本文概述了Hsp的分类、基因和蛋白结构及生物学意义;系统分析了Hsp70或Hsp90、植物寄主辅助因子、病毒的依赖RNA的RNA聚合酶等组分组装形成植物病毒复制酶复合体的机制,Hsp70、Hsp90和病毒组分互作及其亚细胞定位和调控病毒复制的机制;重点阐述了Hsp70与病毒组分互作及运动机制,以及病毒对植物寄主或病毒自身编码Hsp表达的影响,包括Hsps与病毒组分在胞内移动、胞间移动或长距离运动过程中的发生场所、参与要素、能量供应及物质转换机制,病毒诱导植物寄主Hsps表达的种类特异性、动态表达规律等. 目前研究主要集中在Hsps与病毒组分间“两-两”因素,还缺乏超分子复合体中以核酸、蛋白、多糖等为物质基础的多组分间协同机制的研究;建议加强招募蛋白与Hsp间的转位机制、Hsp与超分子蛋白复合体组分间的协作机制、超分子蛋白复合体与植物寄主组织结构间的关系等方面的研究. (图4 表1 参105)
Considerable research has indicated that heat shock proteins (Hsp), as molecular chaperones, carry out many biological activities of plant viruses by folding, transporting, translocating, assembling, or degrading client proteins. It is fundamental to develop resistant plant varieties and novel anti-viral agents by determining the interaction mechanisms between plant viruses and hosts. In this study, we first reviewed the classification, gene and protein structure, and biological significances. We then analyzed the assembling mechanism of Hsp70 or Hsp90, plant host cofactors, and RNA-dependent RNA polymerases in a viral replicase complex, and the mechanism of interaction and subcellular localization between Hsp70 and some plant virus components. We highlighted the mechanism of interaction and movement between Hsp70 and some plant virus components and the effect of Hsp expression of plant hosts or viruses. The results indicated where the mechanism occurred, the participating factors, energy supply, and material conversion between Hsps and the plant virus components for the course of the intracellular movement, local movement between cells, and long-distance movement, and showed the Hsp type specificity and the law of dynamic Hsp expression in plant hosts infected by viruses. The studies mainly focused on the two Hsp factors and the plant viral components, indicating limited coordination mechanisms among many nucleic acids, proteins, and polysaccharides in macromolecular protein complexes (MRC). Future research should analyze the translocation mechanism between client proteins and Hsps, the coordination mechanism between Hsps and MRC components, and the relation between MRC and the plant tissue structure.


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更新日期/Last Update: 2018-04-25