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[1]张晓梅,郭坤,张晟,等.基于主客体识别的温度及氧化还原双重响应型磁性聚合物胶束[J].应用与环境生物学报,2015,21(04):596-601.[doi:10.3724/SP.J.1145.2015.01024]
　ZHANG Xiaomei,GUO Kun,ZHANG Sheng,et al.Temperature and redox dual-responsive magnetomicelles based on host-guest identification[J].Chinese Journal of Applied & Environmental Biology,2015,21(04):596-601.[doi:10.3724/SP.J.1145.2015.01024]
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基于主客体识别的温度及氧化还原双重响应型磁性聚合物胶束()
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《应用与环境生物学报》[ISSN:1006-687X/CN:51-1482/Q]

卷:
21卷
期数:
2015年04期
页码:
596-601
栏目:
研究论文
出版日期:
2015-08-25

文章信息/Info

Title:
Temperature and redox dual-responsive magnetomicelles based on host-guest identification
作者:
张晓梅;  郭坤;  张晟;  李帮经
1中国科学院成都生物研究所 成都 610041 2四川大学高分子研究所高分子材料工程国家重点实验室 成都 610065
Author(s):
ZHANG Xiaomei;  GUO Kun;  ZHANG Sheng;  LI Bangjing
1Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China 2State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China
关键词:
主客体识别; 磁性纳米粒子; 双重响应性; 胶束; 药物载体
Keywords:
host-guest identification;  magnetic nanoparticles;  dual-responsive;  micelles ;  drug carrier
分类号:
R914.4
DOI:
10.3724/SP.J.1145.2015.01024
文献标志码:
A
摘要:
制备磁性纳米粒子和聚合物的复合材料是研究热点，而如何简单高效地构建磁性纳米粒子和聚合物的复合体系是目前研究的难点. 基于此，本研究首先分别制备主体分子CD-MNPs和客体分子mPEG-Fc及PNIPAM-Fc，利用β-CD和二茂铁基团之间的主客体识别作用，在磁性纳米粒子表面构筑两种亲疏水性不同的聚合物链，通过控制温度的变化，使其在水中发生组装，同时通过氧化还原电位的变化，实现组装体系形成和瓦解的可逆变化. 并对得到的胶束进行了载药性能的表征. TEM和DLS的结果显示得到了粒径大概为250 nm的磁性聚合物胶束，并可以通过温度和氧化还原的变化实现胶束的形成和瓦解，而且这种胶束可以作为药物载体，其对抗癌药物阿霉素（Dox）的包封率高达73%. 综上，本研究得到了一种兼具温度和氧化还原敏感的磁性聚合物胶束，这种新型的胶束在药物释放和磁共振成像方面具有潜在的应用前景.
Abstract:
This study aimed to develop an effective and simple magnetic-polymer assembly system. β-CD covered Fe3O4 magnetic nanoparticles (CD-MNPs) was prepared as host molecule while ferrocene terminated polymer polyethylene glycol (mPEG-Fc) and poly(N-isopropylacrylamide) (PNIPAM-Fc) were prepared as guest molecule. Then PEG-Fc and PNIPAM-Fc were attached on the surface of nano magnetic crystal through the host–guest inclusion between ferrocene groups (Fc) and β-CD. The resulting MNPs became amphiphilic in water when the temperature was raised above the LCST of PNIPAM and could be self-assembled into micelles with size around 250 nm, which was characterized by TEM and DLS. Meanwhile, these micelles could disassemble into stable small MNPs after addition of oxidizing agents, and could be formed again after addition of reducing agents. Moreover, the magnetic micelles could serve as a drug carrier with the encapsulation efficiency up to 73% for DOX. Therefore, a novel magnetic micelles with thermal- and redox-responsiveness is obtained, which shows great potential in drug delivery, MRI contrast, and hyperthermia treatment.

参考文献/References:

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备注/Memo

备注/Memo:
国家自然科学基金项目（51373174）、中国科学院知识创新工程项目（KSCX2-EW-J-22）和中国科学院“西部之光”基金资助 Supported by the National Natural Science Foundation of China (51373174), the CAS Knowledge Innovation Program (KSCX2-EW-J-22), and the Western Light Foundation of CAS
更新日期/Last Update: 2015-08-24