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[1]崔旭琴,苏鹏,朱启彧,等.毛兰素诱导结肠癌SW480细胞凋亡的分子机制[J].应用与环境生物学报,2011,17(04):512-516.[doi:10.3724/SP.J.1145.2011.00512]
 CUI Xuqin,SU Peng,ZHU Qiyu,et al.Molecular Mechanism of Apoptosis of Human Colorectal Cancer SW480 Cells Induced by Erianin[J].Chinese Journal of Applied & Environmental Biology,2011,17(04):512-516.[doi:10.3724/SP.J.1145.2011.00512]
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毛兰素诱导结肠癌SW480细胞凋亡的分子机制()
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《应用与环境生物学报》[ISSN:1006-687X/CN:51-1482/Q]

卷:
17卷
期数:
2011年04期
页码:
512-516
栏目:
研究论文
出版日期:
2011-08-25

文章信息/Info

Title:
Molecular Mechanism of Apoptosis of Human Colorectal Cancer SW480 Cells Induced by Erianin
作者:
崔旭琴苏鹏朱启彧安君霞王晶吴坚唐亚雄
(1西南交通大学生命科学与工程学院 成都 610031)
(2中国科学院成都生物研究所 成都 610041)
Author(s):
CUI Xuqin SU Peng ZHU Qiyu AN Junxia WANG Jing WU Jian TANG Yaxiong
(1School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China)
(2Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China)
关键词:
毛兰素人结肠癌细胞SW480细胞增殖细胞凋亡细胞周期石斛中药
Keywords:
erianin SW480 proliferation apoptosis cell cycle Dendrobium Chinese medicine
分类号:
R965 : Q949.718.430.6
DOI:
10.3724/SP.J.1145.2011.00512
文献标志码:
A
摘要:
毛兰素是名贵中药材石斛的活性化合物之一,研究了其对人结肠癌SW480细胞的增殖抑制作用及其诱导的细胞凋亡分子机制. 实验表明,毛兰素能显著抑制结肠癌SW480细胞的增殖,且随着药物浓度与时间增加,抑制率呈明显的剂量时间效应,48 h半数抑制浓度IC50为24.5 nmol/L;毛兰素能显著诱导结肠癌SW480细胞凋亡,并诱导细胞周期阻滞于G2-M期;分子机制研究显示,毛兰素通过下调XIAP、Bcl-xL蛋白表达以及激活Caspase-9、Caspase-7、Caspase-3和PARP活性从而诱导SW480细胞凋亡. 结果表明毛兰素可能对结肠癌的防治具有潜在药用价值. 图6 参17
Abstract:
The antitumor potential of erianin, one of the active compounds of the traditional Chinese medicine, Dendrobium, was investigated. Herein, erianin’s action on proliferation, apoptosis and cycle progression of human colorectal cancer SW480 cells was evaluated especially. The results in vitro demonstrated that erianin significantly suppressed proliferation of SW480 cancer cells in a dose- and time-dependent manner which was associated with induced apoptosis and cell cycle G2-M arrest, and the IC50 value was 24.5 nmol/L after 48 h exposure to erianin. Mechanistically, erianin could down-regulate the expression of XIAP and Bcl-xL proteins, activate Caspase-9, Caspase-7, Caspase-3 and PARP activity, and lead to marked apoptotic inhibitory effect of SW480 cells. These findings suggest that erianin may be a promising antitumor drug for prevention and treatment of colon cancer. Fig 6, Ref 17

参考文献/References:

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相似文献/References:

[1]苏鹏,王晶,安君霞,等.毛兰素对人肝癌Huh7细胞的抑制作用[J].应用与环境生物学报,2011,17(05):662.[doi:10.3724/SP.J.1145.2011.00662]
 SU Peng,WANG Jing,AN Junxia,et al.Inhibitory Effect of Erianin on Hepatocellular Carcinoma (HCC) Huh7 Cells[J].Chinese Journal of Applied & Environmental Biology,2011,17(04):662.[doi:10.3724/SP.J.1145.2011.00662]

备注/Memo

备注/Memo:
中国科学院知识创新工程领域前沿项目(No. KSCX2-EW-J-22)、四川省国际合作计划(No. 2011HH0012)、国家自然科学基金项目(No. 81072662)和中国科学院“西部之光”人才培养计划重点项目资助
更新日期/Last Update: 2011-08-16