|Table of Contents|

Progress in assessing biological effects of magnetic fields using model organism Caenorhabditis elegans(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

Issue:
2015 06
Page:
1003-1011
Research Field:
WRHJ
Publishing date:

Info

Title:
Progress in assessing biological effects of magnetic fields using model organism Caenorhabditis elegans
Author(s):
WANG Jingjing XU An DAI Hui WANG Juan WANG Mudi
1School of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026, China 2Key Laboratory of Ion Beam Bioengineering of Chinese Academy of Sciences and Anhui Province,Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China 3School of Physics and Materials Science, Anhui University, Hefei 230601, China
Keywords:
model organism Caenorhabditis elegans electromagnetic properties of biological tissues electromagnetic radiation magnetic biological effects
CLC:
Q64 : X174
PACS:
DOI:
10.3724/SP.J.1145.2015.07011
DocumentCode:

Abstract:
With the increasing usage of magnetic fields in household appliance, material science, medicine and communication, its effects on human health and the environment have drawn great concern. So far there is no clear and definitive evidence of its negative influence on humans. In recent decades, increasing studies have been performed in order to understand the influence of magnetic fields on living organisms. Among them the model organism Caenorhabditis elegans (C. elegans) plays an important role in exploring the biological effects of magnetic fields, due to its advantages of genetic manipulability, invariant and fully described developmental program, well-characterized genome, easy maintenance, as well as short and prolific life cycle. Biological effects of magnetic fields are found to be closely dependent on the field properties and electromagnetic properties of biological tissues. This review describes the classification of magnetic fields, electromagnetic properties of biological tissues and the advantages of C. elegans in studying magnetic fields. The biological effects of magnetic fields on C. elegans are summarized as slowing growth, shortening life span, decreasing total fecundity, weakening locomotory capability and causing behavior disorders. Results indicate that the biological effects induced by magnetic fields on C. elegans are crucially regulated by the genes associated with development and aging, as well as the pathways related to apoptosis and insulin/IGF-1. The magnetic fields may also increase oxidative stress, enhance energy metabolism and restrict dietary in C. elegans, but the effects may be well tolerated or compensated for by the living organism. The interaction between magnetic fields and organisms is influenced by multiple parameters such as magnetic intensity, exposure time and magnetic field type. Different conditions could lead to opposite results. In addition, this review discusses the toxicity induced by magnetic field exposure, including developmental toxicity in embryos and the larvae stage, reproductive and genetic toxicity during pregnancy. We also reviewed the related new technologies including high throughput sequencing technology for sensitive gene target screening, immunohistochemistry combined with electron microscopic observation to assess epigenetic inheritance phenomenon, and drug delivery system for screening radioprotective agents.

References

1 Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR). Possible effects of electromagnetic fields (EMF) on human health [EB/OL]. Brussels: European Commission, 2007 [accessed date: 2015. 12]. http://ec. europa. eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_007. pdf
2 Kheifets L, Afifi AA, Shimkhada R. Public health impact of extremely low-frequency electromagnetic fields [J]. Environ Health Perspect, 2006, 114 (10): 1532-1537
3 Boyd WA, Smith MV, Freedman JH. Caenorhabditis elegans as a model in developmental toxicology [J]. Methods Mol Boil, 2012, 889: 15-24
4 Leung MCK, Williams PL, Benedetto A, Au C, Helmcke KJ, Aschner M, Meyer JN. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology [J]. Toxicol Sci, 2008, 106 (1): 5-28
5 习岗, 宋清, 杨初平. 异常环境电磁场对生物影响的研究进展[J]. 应用与环境生物学报, 2003, 9 (2): 203-206 [Xi G, Song Q, Yang CP. Research progress about effect of abnormal electromagnetic field on biological system [J]. Chin J Appl Environ Biol, 2003, 9 (2): 203-206]
6 Redlarski G, Lewczuk B, Zak A, Koncicki A, Krawczuk M, Piechocki J, Jakubiuk K, Tojza P, Jaworski J, Ambroziak D, Skarbek L, Gradolewski D. The influence of electromagnetic pollution on living organisms: historical trends and forecasting changes [J]. BioMed Res Int, 2015, 2015: 234098
7 Dini L, Abbro L. Bioeffects of moderate-intensity static magnetic fields on cell cultures [J]. Micron, 2005, 36 (3): 195-217
8 Lee HJ, Kang MH. Effect of the magnetized water supplementation on blood glucose, lymphocyte DNA damage, antioxidant status, and lipid profiles in STZ-induced rats [J]. Nutr Res Pract, 2013, 7 (1): 34-42
9 宋涛, 霍小林, 吴石增. 生物电磁特性及其应用[M]. 北京: 北京工业大学出版社, 2008: 7-15 [Song T, Huo XL, Wu SZ. Electromagnetic Properties and Application of Biological Tissues [M]. Beijing: Beijing University of Technology Publishing House, 2008: 7-15
10 Shen JF, Chao YL, Du L. Effects of staticmagnetic fields on the voltage-gated potassium channel currents in trigeminal root ganglion neurons [J]. Neurosci Lett, 2007, 415 (2):164-168
11 谢茂彬, 刘源岗, 王士斌. 趋磁细菌磁小体形成机制研究进展[J]. 应用与环境生物学报, 2012, 18 (1): 157-162 [Xie MB, Liu YG, Wang SB. Progress in research on formation mechanism of magnetosome in magnetotactic bacteria [J]. Chin J Appl Environ Biol, 2012, 18 (1): 157-162]
12 Vidal-Gadea AG, Ward KA, Truong N, Parikh A, Beron C, Pierce-Shimomura JT. Magnetic orientation in C. elegans is mediated by a pair of magnetosensitive neurons [J]. Integr Comp biol, 2014, 54: E215-E215
13 Brenner S. The genetics of Caenorhabditiselegans [J]. Genetics, 1974, 77 (1): 71-94
14 C. elegans Sequencing Consortium. Genome sequence of the nematode C-elegans: a platform for investigating biology [J]. Science, 1998, 282 (5396): 2012-2018
15 Kaletta T, Hengartner MO. Finding function in novel targets: C-elegansas a model organism [J]. Nat Rev Drug Discovery, 2006, 5 (5): 387-398
16 Perrin AJ, Gunda M, Yu B, Yen K, Ito S, Forster S, Tissenbaum HA, Derry WB. Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways [J]. Cell Death Differ, 2013, 20 (1): 97-107
17 Lezzerini M, Budovskaya Y. A dual role of the Wnt signaling pathway during aging in Caenorhabditis elegans [J]. Aging Cell, 2014, 13 (1): 8-18
18 Hale JJ, Amin NM, George C, Via Z, Shi HR, Liu J. A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C-elegans [J]. Dev Biol, 2014, 389 (2): 137-148
19 Du H, Wang M, Dai H, Hong W, Wang MD, Wang JJ, Weng NY, Nie YG, Xu A. Endosulfanisomers and sulfate metabolite induced reproductive toxicity in Caenorhabditis elegans involves genotoxic response genes [J]. Environ Sci Technol, 2015, 49 (4): 2460-2468
20 Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans [J]. Nature, 2011, 479 (7373): 365-371
21 Krewski D, Acosta D, Andersen M, Anderson H, Bailar JC, Boekelheide K, Brent R, Charnley G, Cheung VG, Green S. Toxicity testing in the 21st century: a vision and strategy [J]. J Toxicol Environ Health-Part B-Crit Rev, 2010, 13 (2-4): 51-138
22 NIH. Tox21: Transforming Environmental Health [EB/OL]. USA: National Institutes of Health, 2012 [accessed date: 2015. 12]. http://www. niehs. nih. gov/news/newsletter/2014/7/spotlight-predictivetox/file695905_508. pdf
23 NAS. Toxicity Testing in the 21st Century: a vision and a strategy [EB/OL]. Washington: National Academies Press, 2007 [accessed date: 2015. 12]. http://dels. nas. edu/resources/static-assets/materials-based-on-reports/reports-in-brief/Toxicity_Testing_final. pdf
24 Lee CH, Hung YC, Huang GS. Static magnetic field accelerates aging and development in nematode [J]. Commun Integr Biol, 2010, 3 (6): 528-529
25 Hung YC, Lee JH, Chen HM, Huang GS. Effects of static magnetic fields on the development and aging of Caenorhabditiselegans [J]. J Exp Biol, 2010, 213 (12): 2079-2085
26 Faustino R, Abrunhosa AJ, Castelo-Branco M, Faustino R, Abrunhosa AJ, Castelo-Branco M. Neuronal and developmental effects of high magnetic fields in the development of an intact living organism: Ceanorhabditis elegans [R]. Coimbra: 2nd IEEE Portuguese Meeting in Bioengineering (ENBENG), 2012
27 Wang L, Du H, Guo XY, Wang XN, Wang MM, Wang YC, Wang M, Chen SP, Wu LJ, Xu A. Developmental abnormality induced by strong static magnetic field in Caenorhabditis elegans [J]. Bioelectromagnetics, 2015, 36 (3): 178-189
28 Lee CH, Chen HM, Yeh LK, Hong MY, Huang GS, Dosage-dependent induction of behavioral decline in Caenorhabditis elegans by long-term treatment of static magnetic fields [J]. J Radiat Res, 2012, 53 (1): 24-32
29 Huang GS, Yeh LK, Chen YC. Nanoparticle-enhanced magnetic field induces apoptosis in nematode [J]. NSTI Nanotech, 2008, 2: 497-500
30 Na HM, Zhang P, Ding YF, Yang L, Wang Y, Zhang HN, Xie ZS, Yang FQ, Cichello S, Liu PS. Proteomic studies of isolated lipid droplets from bacteria, C. elegans, and mammals [J]. Methods Cell Biol, 2013, 116: 1-14
31 Kimura T, Takahashi K, Suzuki Y, Konishi Y, Ota Y, Mori C, Ikenaga T, Takanami T, Saito R, Ichiishi E, Awaji S, Watanabe K, Higashitani A. The effect of high strength static magnetic fields and ionizing radiation on gene expression and DNA damage in Caenorhabditis elegans [J]. Bioelectromagnetics, 2008, 29 (8): 605-614
32 Bessho K, Yamada S, Kunitani T, Nakamura T, Hashiguchi T, Tanimoto Y, Harada S, Yamamoto H, Hosono R. Biological responses in Caenorhabditis elegans to high magnetic field [J]. Experientia, 1995, 51 (3): 284-288
33 高艳. 利用模式生物研究毫米波及微波辐射生物效应及医学防护[D]. 北京: 中国人民解放军军事医学科学院, 2012: 41-51, 73-102 [Gao Y. Biological effect and medical protection of the radiation by millimeter wave and microwave radiation by using Caenorhabditis elegans [D]. Beijing: Academy of Military Medical Sciences, 2012: 41-51, 73-102 ]
34 易健明. 利用高通量测序技术研究电磁辐射加速秀丽线虫发育的分子机制及PCR扩增效率呈倒”S”形曲线降低规律的析因分析[D]. 合肥: 安徽医科大学, 2014: 14-26 [Yi JM. Investigation of the molecular mechanism underlie the rapid development of C. elegans induced by electromagnetic fields using high-through sequencing technology and the driving force behing the overall inverse-S shaped curve of the amplification efficiency in PCR reaction [D]. Hefei: Anhui Medical University, 2014: 14-26]
35 de Pomerai DI, Dawe A, Djerbib L, Allan J, Brunt G, Daniells C. Growth and maturation of the nematode Caenorhabditis elegans following exposure to weak microwave fields [J]. Enzyme Microb Technol, 2002, 30 (1): 73-7937
36 Bojjawar T, Jalari M, Aamodt E, Ware MF, Haynie DT. Effect of electromagnetic nanopulses on C. elegans fertility [J]. Bioelectromagnetics, 2006, 27 (7): 515-520
37 Fritze K, Wiessner C, Kuster N, Sommer C, Gass P, Hermann DM, Kiessling M, Hossmann KA. Effect of global system for mobile communication microwave exposure on the genomic responseof the ratbrain [J]. Neuroscience, 1997, 81 (3): 627-639
38 Miyakawa T, Yamada S, Harada S, Ishimori T, Yamamoto H, Hosono R. Exposure of Caenorhabditis elegans to extremely low frequency high magnetic fields induces stress responses [J]. Bioelectromagnetics, 2001, 22 (5): 333-339
39 Junkersdorf B, Bauer H, Gutzeit HO. Electromagnetic fields enhance the stress response at elevated temperatures in the nematode Caenorhabditiselegans [J]. Bioelectromagnetics, 2000, 21 (2): 100-106
40 de Pomerai D, Daniells C, David H, Allan J, Duce I, Mutwakil M, Thomas D, Sewell P, Tattersall J, Jones D, Candido P. Non-thermal heat-shock response to microwaves [J]. Nature, 2000, 405: 417-418
41 Dawe AS, Smith B, Thomas DWP, Greedy S, Vasic N, Gregory A, Loader B, de Pomerai DI. A small temperature rise may contribute towards the apparent induction by microwaves of heat-shock gene expression in the nematode Caenorhabditis elegans [J]. Bioelectromagnetics, 2006, 27 (2): 88-97
42 Shi ZH, Yu H, Sun YY, Yang CJ, Lian HY, Cai P. The Energy Metabolism in Caenorhabditis elegans under the extremely low-frequency electromagnetic field exposure [J]. Sci Rep, 2015, 5: 8471
43 Webb SJ, Stoneham ME. Resonances between 1011 and 1012 Hz in active bacterial-cells as seen by laser raman-spectroscopy [J]. Phys Lett A, 1977, 60 (3): 267-268
44 Webb SJ, Stoneham ME, Frohlich H. Evidence for nonthermal excitation of energy-levels in active biological-systems [J]. Phys Lett A, 1977, 63 (3): 407-408
45 Bawin SM, Adey WR, Sabbot IM. Ionic factors in release of45Ca2+from chicken cerebral tissue by electromagnetic-fields [J]. Proc Natl Acad Sci USA, 1978, 75 (12): 6314-6318
46 Wang C, Zhou H, Peng R, Wang L, Su Z, Chen P, Wang S, Wang S, Liu Y, Cong J, Wu K, Hu X, Fan E. Electromagnetic pulse reduces free radical generation in rat liver mitochondria in vitro [J]. Free Radical Res, 2013, 47 (4): 276-282
47 Elmore RD, Crawford L. Remanence in authigenic magnetite-testing the hydrocarbon-magnetite hypothesis [J]. J Geophys Res-Solid Earth Planets, 1990, 95 (B4): 4539-4549
48 Hellinger J, Hoffmann KP. Magnetic field perception in the rainbow trout Oncorynchus mykiss: magnetite mediated, light dependent or both?[J]. J Comp PhysiolA, 2012, 198 (8): 593-605
49 Daniells C, Duce I, Thomas D, Sewell P, Tattersall J, de Pomerai D. Transgenic nematodes as biomonitors of microwave-induced stress [J]. Mutat Res, 1998, 339 (1): 55-64

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