|Table of Contents|

Recent progress in studies of synthetic microbial community and its applications in bioengineering(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

Issue:
2015 06
Page:
981-986
Research Field:
WRHJ
Publishing date:

Info

Title:
Recent progress in studies of synthetic microbial community and its applications in bioengineering
Author(s):
ZHANG Zhaojing LI Shuzhen DENG Ye LI Huijie LI Duanxing LIU Ziyan WANG Jingwei SHEN Wenli MA Qiao QU Yuanyuan ZHOU Jiti
1Key Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education, School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China 2Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Science, Beijing 100085, China
Keywords:
synthetic microbial communities interspecies interactions microbial regulations bioengineering
CLC:
Q938.1 + Q939.9
PACS:
DOI:
10.3724/SP.J.1145.2015.03027
DocumentCode:

Abstract:
Synthetic microbial community represents an emerging frontier of synthetic biology at the level of microbial community and their applications have recently gained a lot of interest worldwide. This study reviews the characteristics, interspecies interactions, microbial regulations, and applications of synthetic microbial communities in bioengineering. Synthetic microbial communities, composed of multiple species with well-defined genetic background, can accomplish specific functions through interactions among microorganisms. These synthetic communities are characterized with low complexity, high controllability and stability. Various interactions may exist in synthetic microbial communities, including mutualism (cooperation), commensalism, parasitism or predation, and competition. These interactions can be regulated by modifying the cell-cell communication, metabolic pathway and spatial structures, thus achieving engineering of synthetic communities. In the last few years, synthetic microbial communities have been widely used in the field of bioprocessing, focusing on fuel production, synthesis of high-value chemicals, and pollutants bioremediation. However, the interactions in synthetic microbial communities have not been fully parsed yet, leaving limited capacity for simultaneous regulating the composition and function of the communities. Therefore, it should be the focus of future research to combine the synthetic biology, systematic biology and bioinformatics to rationally design and fabricate stable and efficient synthetic microbial communities, as well as to optimize and regulate the bioprocesses.

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