|Table of Contents|

Analysis and Prediction of Protein Interaction Network of Ralstonia solanacearum(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

Issue:
2012 01
Page:
139-146
Research Field:
T & M
Publishing date:

Info

Title:
Analysis and Prediction of Protein Interaction Network of Ralstonia solanacearum
Author(s):
JIANG Chunlei ZHAO rui LÜ Lingfeng QIAO Dairong CAO Yi
(Sichuan Public Experiment Platform of Bioinformatics and Metabolic Engineering, College of Life Sciences, Sichuan University, Chengdu 610064, China)
Keywords:
Ralstonia solanacearum protein interaction networks protein function proteomic bacterial wilt Naïve Bayes model
CLC:
S432 : Q936
PACS:
DOI:
10.3724/SP.J.1145.2012.00139
DocumentCode:

Abstract:
Bacterial wilt caused by Ralstonia solanacearum is a worldwide soil-borne bacterial diseases. The complete sequence of Ralstonia solanacearum genome make it possible to analysis the protein-protein interaction networks of R. solanacearum from the proteomic. In this paper, Naïve Bayes model was used to integrate seven kinds of methods (Phylogenetic profile, gene neighbor method, gene fusion, operon method, interolog, microarray, domain interactions) and predict protein interactions of R. solanacearum. The reliable networks were obtained based on threshold determined by Youden’s index. The secretion system and signal transduction system were analyzed and possible drug targets (cyaB, pilD, Fli, Rsp1526, VsrA, VsrB, PilH) were suggested. The function of proteins without comments in COG database was inferred according to protein-protein interaction. A completely free online database support was provided, including convenient queries and download for R. solanacearum protein interaction and function data (http://www.scbmp.org.cn/rsoppi.php). Fig 8, Tab 1, Ref 25

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Last Update: 2012-02-29