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Study on antivirus activity of sulfated Polygonatum odoratum oligosaccharide(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

Issue:
2000 Vol.06 No.5
Page:
483-486
Research Field:
Reviews
Publishing date:

Info

Title:
Study on antivirus activity of sulfated Polygonatum odoratum oligosaccharide
Author(s):
YANG Minet al.
Keywords:
Keywords Polygonatum odoratum oligosaccharide sulfate Herp es simplex virus type 2(HSV2) cytotoxicity antivirus activity
CLC:
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PACS:
DOI:
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DocumentCode:

Abstract:
Abstract Poos, a kind of oligosaccharide extracted from Polygonatum odoratum (Mill.) Druce (a kind of Chinese herb), was sulfated to obtain SPoos with chlorosulfur acidpyridine. IR showed adsorption at 1 250, 810 cm-1 . The sulfur content of SPoos was found to be 8.47%. The average degree of sub stitution was 0.6. The hydroxy group of SPoos was esterified by chlorosulfur acid. Cytotoxicity in Vero cell, and antivtus activity of Poos and SPoos were investigated in vitro. Poos and SPoos both showed no cytotoxi city in Vero cell. Poos itself did not inhibit the cytopathic effect and plaque forming of Herpes simplex virus type 2(HSV2) in Vero cell, but its sulfated de rivative obtained antivirus activity, which could well inhibit the cytopathic effect of HS V2 at concentrations of 125~2 000 μg/mL, and completely inhibit plaque forming of HSV2 at concentrations as low as 200 μg/mL. Fig 4, Tab 2, Ref 12

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Last Update: 2002-11-05