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The effects of cytochalasin B on micronucleus frequencies in CHL cells and human blood lymphocytes(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

Issue:
2000 Vol.06 No.4
Page:
341-343
Research Field:
Reviews
Publishing date:

Info

Title:
The effects of cytochalasin B on micronucleus frequencies in CHL cells and human blood lymphocytes
Author(s):
MENG Ziqianget al.
Keywords:
Keywords human blood lymphocytes CHL cells cytochalasin B micronuclei cell cycle
CLC:
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PACS:
DOI:
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DocumentCode:

Abstract:
Abstract On the basis of micronuclei (MN) formation theory, the effects of cytochalasin B at different concentrations on mitotic cycle and micronucleus frequencies of CHL cells and human blood lymphocytes were studied.The results showed that cytochalasin B at high concentrations could increase the micronucleus frequencies in two kinds of cells, and could also increase the background of MN frequency in control group and decrease the sensitivity and accuracy of the experiments. So the favorite concentration of cytochalasin B is 3 μg/mL for CHL cell micronuclei experiments and 2~4 μg/mL for human blood lymphocyte. Tab 4, Ref 9

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Last Update: 2002-11-04