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Anti-tumor Activity of Crude Saponin from Anemone raddeana Regel(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

Issue:
2008 No.03
Page:
378-382
Research Field:
Reviews
Publishing date:

Info

Title:
Anti-tumor Activity of Crude Saponin from Anemone raddeana Regel
Author(s):
WANG Mingkui et al.
(Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China)
Keywords:
Keywords Anemone raddeana Regel crude saponin tumor inhabitation acute toxicity
CLC:
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PACS:
DOI:
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DocumentCode:

Abstract:
Abstract The crude saponin from Anemone raddeana Regel was prepared by hydrolysis and solvent extraction. The major component was raddeanin A which accounted for 20% of crude saponin. Its anti-tumor activity in-vitro and in vivo was investigated. The inhabitation on KB, HCT-8, MCF-7WT and MCF-7/ADR was measured with MTT in-vitro, and the IC50 was 7.68, 18.52, 17.34 and 19.43 mg/mL respectively, with no cross-resistance to epirubicin. The inhabitation on tumor S180, liver cancer H22 and EAC mice was measured in vivo. By intragastric infusion at 1 g/kg, the inhabitation on S180, H22 and EAC was 68.1%, 62.5% and 69.3%, respectively. The acute toxicity of the crude saponin was also measured. The LD50 of intragastric infusion and intra-peritoneal administration were 5.7 g/kg and 106 mg/kg. Therefore, the crude saponin prepared in this way had good inhibitory activity on tumors in-vitro and in vivo, indicating the saponin was possibly a potential anti-cancer medicine. Tab 7, Ref 9

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Last Update: 2008-07-01