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Chemical constituents of the endophytic fungus Fusarium tricinctum from Ligusticum chuanxiong Hort. *(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

Issue:
2020 02
Page:
1-7
Research Field:
Articles
Publishing date:

Info

Title:
Chemical constituents of the endophytic fungus Fusarium tricinctum from Ligusticum chuanxiong Hort. *
Author(s):
CAO Yumei1 JIN Meng ying1 TAN Lu 1 LUO Yu2 HU Jing wen1 ZHAO Jiajia1 GUO Da le1** & DENG Yun 1**
1Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Sichuan provincial Key Laboratory of Systematic Research , Development and Utilization of Chinese Medical Resources : Ministry of State Key Laboratory Breeding Base, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2School of Pharmacy, Southwest Medical University, Luzhou 646000, China
Keywords:
Ligusticum chuanxiong Hort. endophytic fungus Fusarium tricinctum structure identification cytotoxicity
CLC:
-
PACS:
DOI:
10.19675/j.cnki.1006-687x.2019.06005
DocumentCode:

Abstract:
To investigate the c ompounds produced by the e ndophytic fungus Fusarium tricinctum from Ligusticum chuanxiong Hort. and the ir cytotoxicity against three tumor cell lines, F. tricinctum was cultured with brown rice and its secondary metabolites were purified by chromatographic procedures and identified on the basis of NMR, ESI-MS and other spectral evidences. The MTT method wa s applied to test the cytotoxicity of the isolated compounds. Finally 13 compounds were isolated and identified phenylacetic acid ( 1), 3,6-diisopropyl-1-methylpiperazine-2,5-dione ( 2), fusarpyrone A ( 3), fusagerin B ( 4), N-phenethylacetamide (5), fungerin (6), callyspongidipeptide A (7), cyclo-((S)-Pro-(R)-Leu) ( 8), vomifolilol (9), cyclo-(4-S-hydroxy-R-proline-R-isoleucine) ( 10), N-acetyl-β-oxotryptamine (11), nicotinic acid (12), 2-hydroxybenzeneacetic acid ( 13). Compound 6 showed weak inhibitory activity against OCI-LY10, HT29, MV4-11, Hela and SKOV3 cells , with the successive IC50 values of 23.98±2.37, 93.63±1.42, 90.64±1.65, 77.65±1.35 and 52.52 ±2.04 μmol/L.

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Last Update: 2019-07-30