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Effect of Intestinal Microbes on the Immune System and the Latest Research Methods(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

2013 03
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Effect of Intestinal Microbes on the Immune System and the Latest Research Methods
CHEN DandanGU ShenghuaZHANG JinnaBAO FukaiTANG YueqingWU Xiaolei
(1Department of Microbiology and Immunology, Kunming Medical College, Kunming 650031, China)
(2College of Engineering, Peking University, Beijing 100871, China)
gut microbiota immune system autoimmunity 16S rDNA metagenomics

The complex intestinal microbial ecology is closely related with the immune system of organisms. Gut flora not only regulates the secretion of IgA to influence intestinal mucosal immunity by preventing invasion of pathogenic microorganisms, but also affects extra-intestinal immune system and plays an important role in the development of autoimmune diseases. The gut flora is usually studied with molecular biological techniques based on 16S rRNA, such as pyrosequencing, gene chip and metagenomic sequencing methods, each with its own advantages. Future experimental data of gut flora acquired with cross-disciplinary approaches of ecology, microbiology and advanced computational methods are expected to provide prevention and treatment for immune diseases.


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Last Update: 2013-06-20