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Inhibitory Effect of Erianin on Hepatocellular Carcinoma (HCC) Huh7 Cells(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

2011 05
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Inhibitory Effect of Erianin on Hepatocellular Carcinoma (HCC) Huh7 Cells
SU PengWANG JingAN JunxiaZHU QiyuLU XiaoxiaTANG Yaxiong
(Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China)
erianin hepatocellular carcinoma (HCC) Huh7 proliferation apoptosis cell cycle
R965 : Q949.718.430.6

Erianin, a low molecular-weight natural product isolated from Dendrobium chrysotoxum Lind., is often used as an anti-pyretic and an analgesic in traditional Chinese medicine. Herein, this study evaluated the erianin’s effect on cell proliferation, apoptosis and cell cycle progression of hepatocellular carcinoma (HCC) Huh7 cancer cells especially. The results in vitro demonstrated that erianin significantly suppressed proliferation of Huh7 cancer cells in a dose- and time-dependent manner which was associated with induced apoptosis and cell cycle G2-M arrest, and the IC50 value was 37.4 nmol/L after 48 h exposure to erianin. Mechanistically, erianin could inhibit Akt activation, down-regulate the expression of Mcl-1 protein, and activate the cleavage of PARP in a dose- and time-dependent manner, leading to marked inhibitory effect of Huh7 cells. These findings suggest that erianin may be a promising antitumor drug for prevention and treatment of HCC. Fig 5, Ref 17


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Last Update: 2011-10-25