|Table of Contents|

Acetyl-coenzyme A Carboxylase: A Key Metabolic Enzyme of Fatty Acid and Progress of Its Gene Clone(PDF)

Chinese Journal of Applied & Environmental Biology[ISSN:1006-687X/CN:51-1482/Q]

Issue:
2011 05
Page:
753-758
Research Field:
Reviews
Publishing date:

Info

Title:
Acetyl-coenzyme A Carboxylase: A Key Metabolic Enzyme of Fatty Acid and Progress of Its Gene Clone
Author(s):
LI JieqiongZHENG ShixueYU ZiniuZHANG Jibing
(State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China)
Keywords:
acetyl-coenzyme A carboxylases fatty acid metabolism function domain inhibitor gene cloning
CLC:
Q55 + Q78
PACS:
DOI:
10.3724/SP.J.1145.2011.00753
DocumentCode:

Abstract:
Acetyl-coenzyme A carboxylases (ACCs) have crucial roles in fatty acid metabolism in most living organisms. In this article, structure, types, functions and inhibitors of ACC, as well as research status of ACC gene clone are systematically discussed. ACC is a multi-subunit enzyme in most prokaryotes, whereas it is a large, multi-domain enzyme in most eukaryotes. In addition, there are two special types found from Streptomyces coelicolor and Metallosphaera sedula. All of these types contain three key domains: Biotin carboxylase (BC), biotin carboxyl carrier protein (BCCP) and carboxyltransferase (CT). CT domain, as a candidate target, has been widely used for screening of plant herbicides and drug development against obesity, diabetes and other symptoms of the metabolic syndrome. The gene encoded ACC is also becoming an important target gene applied in the fields of transgenic oil plants and biodiesel. Previous studies showed that β-CT in plant plasmid was the limit factor of heteromeric ACC, and BCCP was a negative regulator of fatty acid synthesis. Lipid synthesis metabolism is a very complex network, especially feedback inhibition mechanism exists in it. As a result, cloning and expression of ACC gene may increase the activity of ACC in the host, but not necessarily could obviously promote the accumulation of fatty acid. Fig 2, Ref 52

References

1 Harwood HJ Jr. Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome. Curr Opin Investig Drugs, 2004, 5 (3): 283~289
2 Herbert D, Walker KA, Price L. Acetyl-CoA carboxylase - a graminicide target sit. Pestic Sci, 1997, 50 (1): 67~71
3 Cronan JE Jr, Waldrop GL. Multi-subunit acetyl-CoA carboxylases. Prog Lipid Res, 2002, 41 (5): 407~435
4 Choi-Rhee E, Cronan JE Jr. The biotin carboxylase-biotin carboxyl carrier protein complex of Escherichia coli acetyl-CoA carboxylase. J Biol Chem, 2003, 278 (33): 30806~30812
5 Nikolau BJ, Ohlrogge JB, Wurtele ES. Plant biotin-containing carboxylases. Arch Biochem Biophys, 2003, 414 (2): 211~222
6 Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ. The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad. Sci USA, 2000, 97 (4): 1444~1449
7 Elborough KM, Winz R, Deka RK, Markham JE, White AJ, Rawsthorne S, Slabas AR. Biotin carboxyl carrier protein and carboxyltransferase subunits of the multi-subunit form of acetyl-CoA carboxylase from Brassica napus: Cloning and analysi s of expression during oilseed rape embryogenesis. Biochem J, 1996, 3l5 (Pt 1): l03~112
8 Schulte W, Topfer R, Stracke R, Schell J, Martini N. Multifunctional acetyl-CoA carboxylase from Brassica napus is encoded by a multi-gene family: Indication for plastidic 1ocalization of at least one isoform. Proc Natl Acad Sci USA, 1997, 94 (7): 3465~3470
9 Burle G, David A, Donald L, John W, Margaret A, Sheila M. Transgenic plants expressing maize acetyl-CoA carboxylase gene and method of altering oil content. US, Patent, US 6222099. April 24, 2001
10 Diacovich L, Peiru S, Kurth D, Rodriguez E, Podesta F, Khosla C, Gramajo H. Kinetic and structural analysis of a new group of acyl-CoA carboxylases found in Streptomyces coelicolor A3(2). J Biol Chem, 2002, 277 (34): 31228~31236
11 Zha WJ, Rubin-Pitel SB, Shao ZY, Zhao HM. Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering . Metab Eng, 2009, 11 (3): 192~198
12 Hugler M, Krieger RS, Jahn M, Fuchs G. Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Eur J Biochem, 2003, 270 (4): 736~744
13 Tong L. Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery. Cell Mol Life Sci, 2005, 62 (16):1784~1803
14 Sasaki Y, Nagano Y. Plant acetyl-CoA carboxylase: Structure, biosynthesis, regulation and gene manipulation for plant breeding. Biosci Biotechnol Biochem, 2004, 68 (6): 1175~1184
15 Munday MR. Regulation of mammalian acetyl-CoA carboxylase. Biochem Soc Trans, 2002, 30 (Pt 6): 1059~1064
16 Abu-Elheiga L, Oh W, Kordari P, Wakil SJ. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc Natl Acad Sci USA, 2003, 100 (18): 10207~10212
17 Gronwald JW. Lipid biosynthesis inhibitors. Weed Sci, 1991, 39: 435~449
18 Turner JA, Pernich DJ. Origin of enantiomeric selectivity in the aryloxyphenoxypropionic acid class of herbicidal acetyl coenzyme A carboxylase (ACCase) inhibitors. J Agric Food Chem, 2002, 50 (16): 4554~4566
19 Ratledge C. Fatty aid biosynthesis in microorganisms being used for single cell oil production. Biochimie, 2004, 86 (11): 807~815
20 Meng X, Yang JM, Cao YJ, Li LZ, Jiang XL, Xu X, Liu Wei, Xian M, Zhang YW. Increasing fatty acid production in E. coli by simulating the lipid accumulation of oleaginous microorganisms. J Ind Microbiol Biotechnol, 2010, DOI 10.1007/s10295-010-0861-z
21 Davis MS, Solbiati J, Cronan JE. Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli. J Biol Chem, 2000, 275 (37): 28593~28598
22 Foster DW. The role of the carnitine system in human metabolism. Ann N Y Acad Sci, 2004, 1033: 1~16
23 Harwood HJ Jr, Petras SF, Shelly LD, Zaccaro LM, Perry DA, Makowski MR, Hargrove DM, Martin KA, Tracey WR, Chapman JG, Magee WP, Dalvie DK, Soliman VF, Martin WH, Mularski CJ,Eisenbeis SA. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem, 2003, 278 (39): 37099~37111
24 Yang XY, Guschina IA, Hurst S, Wood S, Langford M, Hawkes T, Harwood JL.The action of herbicides on fatty acid biosynthesis and elongation in barley and cucumber. Pest Manage Sci, 2010, 66 (7): 794~800
25 Zhang H, Yang Z, Shen Y, Tong L. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science, 2003, 299 (5615): 2064~2067
26 Zhang H, Tweel B, Tong L. Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by haloxyfop and diclofop. Proc Natl Acad Sci USA, 2004, 101 (16): 5910~5915
27 Tong L, Harwood Jr JH. Acetyl-coenzyme A carboxylases: Versatile targets for drug discovery. J Cell Biochem, 2006, 99 (6):1476~1488
28 Kaundun SS. An aspartate to glycine change in the carboxyl transferase domain of acetyl CoA carboxylase and non-target-site mechanism(s) confer resistance to ACCase inhibitor herbicides in a Lolium multiflorum population. Pest Manage Sci, 2010, 66 (11): 1249~1256
29 Délye C, Matéjicek A, Michel S. Cross-resistance patterns to ACCase-inhibiting herbicides conferred by mutant ACCase isoforms in Alopecurus myosuroides Huds. (black-grass) re-examined at the recommended herbicide field rate. Pest Manage Sci, 2008, 64 (11): 1179~1186
30 Jump DB, Gonzalez TM, Olson LK. SoraphenA, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol, 2011, 81 (5): 649~660
31 Shen Y, Volrath SL, Weatherly SC, Elich TD, Tong L. A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. Mol Cell, 2004, 16 (6): 881~891
32 Pohlmann J, Lampe T, Shimada M, Nell PG, Pernerstorfer J, Svenstrup N, Brunner NA, Schiffer G, Freiberg C. Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action. Bioorg Med Chem Lett, 2005, 15 (4): 1189~1192
33 Miyahisa I, Kaneko M, Funa N, Kawasaki H, Kojima H, Ohnishi Y, Horinouchi S. Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster. Appl Microbiol Biotechnol, 2005, 68 (4): 498~504
34 Gu KY, Chiama HH, Tiana DS, Yina ZC. Molecular cloning and expression of heteromeric ACCase subunit genes from Jatropha curcas. Plant Sci, 2011, 180 (4): 642~649
35 Zhang YX (张熠星), Cui Y (崔燕), Zhu JB (祝建波), Zhou P (周鹏). Construction of plant expression vector on accD gene fom Gossypuum hirsutum and its genetic transformation. Chin Agri Sci Bull (中国农业通报), 2009, 25 (18): 36~40
36 Alisa N, Wilaiwan C, Theera E, Amornrat P. Cloning and expression of a plastid-encoded subunit, beta-carboxyltransferase gene (accD) and a nuclear-encoded subunit, biotin carboxylase of acetyl-CoA carboxylase from oil palm (Elaeis guineensis Jacq.). Plant Sci, 2008, 175 (4): 497~504
37 Li YQ, Sueda SJ, Kondo H,Kawarabayasi Y. A unique biotin carboxyl carrier protein in archaeon Sulfolobus tokodaii. FEBS Lett, 2006, 580 (6): 1536~1540
38 Yakimov MM, Cono VL, Denaro R. A first insight into the occurrence and expression of functional amoA and accA genes of autotrophic and ammonia-oxidizing bathypelagic Crenarchaeota of Tyrrhenian Sea. Deep Sea Res II, 2009, 56 (11~12): 748~754
39 Kurth DG, Gago GM, Lglesia ADL, Lyonnet BB, Lin TW, Morbidoni HR, Tsai SC, Gramajo H. ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in Mycobacteria. Microbiology, 2009, 155 (Pt 8): 2664~2675
40 Madoka Y, Tomizawa K, Mizoi J. Chloroplast transformation with modified accD operon increases acetyl-CoA carboxylase and causes extension of leaf longevity and increase in seed yield in tobacco. Plant Cell Physiol, 2002, 43 (12): 1518~1525
41 Kode V, Mudd EA,Lamtham S, Day A. The tobacco plastid accD gene is essential and is required for leaf Development. Plant J, 2005, 44 (2): 237~244
42 Feria Bourrellier AB, Valot B, Guillot A, Ambard-Bretteville F, Vidal J, Hodges M. Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate–regulated by interaction of PII with the biotin carboxyl carrier subunit. Proc Natl Acad Sci USA, 2010, 107 (1): 502~507
43 Hu YP (胡亚平), Xia YP (夏玉平), Wu G (吴刚), Wu YH (武玉花), Xiao L (肖玲), Li J (李均), Lu CM (卢长明). An overlap extension PCR method used in isolation of long cDNAs of acetyl-coA carboxylase from Arabidopsis. Chin J Oil Crop Sci (中国油料作物学报), 2009, 31 (4): 407~412
44 Cheng D, Chu CH, Cheng LP, Feder JN, Mintier GA, Wu YL, Cook JW, Harpel MR, Locke GA, An Y, Tamura JK. Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes. Protein Express Pur, 2007, 51 (1): 11~21
45 Kaushik VK, Kavana M, Volz JM, Weldon SC, Hanrahan S, Xu J, Caplan SL, Hubbard BK. Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics. Biochim Biophys Acta, 2009, 1794 (6): 961~967
46 Campa D, Husing A, Claude JC, Dostal L, Boeing H, Kroger J, Tjønneland A, Roswall N, Overvad K, Dahm CC, Rodriguez L, Sala N, Perez MJ, Larranaga N, Chirlague MD, Ardanaz E, Khaw KT, Wareham N, Allen NE, Travis RC, Trichopoulou A, Naska A, Bamia C, Palli D, Sieri S, Tumino R, Sacerdote C, van Kranen HJ, Bas Bueno-de-Mesquita H, Stattin P, Johansson M, Chajes V, Rinaldi S, Romieu I, Siddiq A, Norat T, Riboli E, Kaaks R, Canzian F. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). Eur J Canser, 2011, 47 (3): 420~427
47 Ruenwai R, Cheevadhanarak S, Laoteng K. Overexpression of acetyl-CoA carboxylase gene of Mucor rouxii enhanced fatty acid content in Hansenula polymorpha. Mol Biotechnol, 2009, 42 (3): 327~332
48 Roessler PG, Ohlrogge JB. Cloning and characterization of the gene that encodes acetyl-coenzyme A carboxyIase in the alga cyclotella cryptica. J Biol Chem, 1993, 268 (26): 19254~19259
49 Dunahay TG, Jarvis EE, Roessler PG. Genetic transformation of the diatoms Cyclotella cryptica and Navicula saprophiha. J Phycol, 1995, 31 (6): 1004~1012
50 Song DH (宋东辉), Hou LJ (候李君), Shi DJ (施定基). Exploitation and utilization of rich lipids-microalgae, as new lipids feedstock for biodiesel production – a review. Chin J Biotech (生物工程学报), 2008, 24 (3): 341~348
51 Davis MS, Cronan JE, JR. Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein. J Bacteriol, 2001, 183 (4): 1499~1503
52 Kubis SE, Pike MJ, Everett CJ, Hill LM, Rawsthome S. The import of phosphoenolpyruvate by plastids from developing embryos of oilseed rape, Brassica napus (L.) and its potential as a substrate for fatty acid synthesis. J Exp Bot, 55 (402): 1455~1462

Memo

Memo:
-
Last Update: 2011-10-25